Succinamide → 1-(2-Bromoethyl)pyrrolidine-2,5-dione

HRID 1461416Notes

Reaction equation

HRID 1461416 reaction equation
[C:1]([NH2:8])(=[O:7])[CH2:2][CH2:3][C:4](N)=[O:5].[Br:9][CH:10](Br)[CH3:11].C(=O)([O-])[O-].[K+].[K+]>CC(=O)CC>[Br:9][CH2:10][CH2:11][N:8]1[C:1](=[O:7])[CH2:2][CH2:3][C:4]1=[O:5]

Participants

5

Reactant 3

HCID 8036SuccinamideHCID 112011,1-DibromoethaneHCID 11430Potassium Carbonate

Product 1

HCID 135613951-(2-Bromoethyl)pyrrolidine-2,5-dione

Reagents, catalysts & solvents 1

HCID 6569Methyl Ethyl KetoneSolvent

Procedure

49.5 g of succinamide was dissolved in 750 ml of 2-butanone under heating. 187.9 g of dibromoethane and 138 g of anhydrous potassium carbonate were added to the solution and the mixture was heated under reflux for 9.5 h.

Workup

  1. temperatureunder heating
  2. temperaturethe mixture was heated
  3. temperatureunder reflux for 9.5 h.

Sources & evidence

ORD record
ord-cea0d1dc653d4b7d987b3ec6529e1f87
Source dataset
uspto-grants-1991_12
Patent number
US05075335

Reaction notes

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