Methylamine → Ethyl 3-methyl-3-(methylamino)butanoate
Reaction equation
[CH3:1][C:2]([CH3:9])=[CH:3][C:4]([O:6][CH2:7][CH3:8])=[O:5].[CH3:10][NH2:11]>C(O)C>[CH3:1][C:2]([NH:11][CH3:10])([CH3:9])[CH2:3][C:4]([O:6][CH2:7][CH3:8])=[O:5]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
A mixture containing ethyl 3,3-dimethylacrylate (100 g) and methylamine (140 ml of a 33% solution in ethanol) in ethanol (400 ml) was allowed to stand at room temperature for 2 weeks. The mixture was concentrated in vacuo to give an oil which was fractionally distilled in vacuo to give the title compound as a colourless, mobile oil, yield, 95.0 g, b.p. 68°-75°/20 mm.Hg.
Workup
- waitto stand at room temperature for 2 weeks
- concentrationThe mixture was concentrated in vacuo
- customto give an oil which
- distillationwas fractionally distilled in vacuo
Sources & evidence
- ORD record
- ord-d9f90ad167274f23b09d13c88d1d2709
- Source dataset
- uspto-grants-1994_04
- Patent number
- US05300516
Reaction notes
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