Propylene Oxide → HCID 86747740, compound

Reaction equation

C(OC([NH:11][CH2:12][CH2:13][CH2:14][O:15][P:16]([CH2:19][CH2:20][CH2:21][CH3:22])(=[O:18])[OH:17])=O)C1C=CC=CC=1.C1OC1C>Cl.CO>[NH2:11][CH2:12][CH2:13][CH2:14][O:15][P:16]([CH2:19][CH2:20][CH2:21][CH3:22])(=[O:17])[OH:18]

Participants

Procedure

A solution of 6.7 g of 3-(benzyloxycarbonylamino)propyl(n-butyl)phosphonic acid in 125 ml of 36% hydrochloric acid is heated at reflux for 1.5 hour. The mixture is evaporated to an oil and the oil is co-evaporated with water (2×50 ml) to give a white solid. This solid is then dissolved in 50 ml of dry methanol, 1-3 ml of propylene oxide is added and the solution is stirred at room temperature. The precipitated product is collected by filtration and dried to give 3-aminopropyl(n-butyl)phosphonic acid, m.p. 231°-234° (dec.), 31P-NMR: δ=+44.6 ppm (D2O).