Isopropyl 3-aminopropyl(ethyl)phosphinate → Cgp-36216
Reaction equation
[NH2:1][CH2:2][CH2:3][CH2:4][P:5]([CH2:11][CH3:12])(=[O:10])[O:6]C(C)C>Cl>[NH2:1][CH2:2][CH2:3][CH2:4][P:5]([CH2:11][CH3:12])(=[O:6])[OH:10]Participants
3
Reactant 1
Product 1
Reagents, catalysts & solvents 1
Procedure
A mixture of 7.73 g of isopropyl 3-aminopropyl(ethyl)-phosphinate and 40 ml of 20% hydrochloric acid is refluxed with stirring for 14 hours. The clear solution is evaporated to dryness and the residue is recrystallized from methanol/propylenoxide to give 3-aminopropyl(ethyl)phosphinic acid as a white solid, m.p. 233°-239°; 1H-NMR (D2O): 0.4-1.8 (m, 9H, PCH2CH2 and PCH2CH3); 2.7 (t, 2H, NCH2); 4.55 (s, 3H, OH, NH2).
Workup
- temperatureis refluxed
- customThe clear solution is evaporated to dryness
- customthe residue is recrystallized from methanol/propylenoxide
Sources & evidence
- ORD record
- ord-a2493e04b7e14229a9816dfe5013b4cb
- Source dataset
- uspto-grants-1994_04
- Patent number
- US05300679
Reaction notes
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