Ammonia → Isopropyl 3-aminopropyl(ethyl)phosphinate
Reaction equation
[C:1]([CH2:3][CH2:4][P:5]([CH2:11][CH3:12])(=[O:10])[O:6][CH:7]([CH3:9])[CH3:8])#[N:2].N.[H][H]>C(O)(C)C.[Ni]>[NH2:2][CH2:1][CH2:3][CH2:4][P:5]([CH2:11][CH3:12])(=[O:10])[O:6][CH:7]([CH3:9])[CH3:8]Participants
6
Procedure
To 34.1 g of isopropyl 2-cyanoethyl(ethyl)phosphinate in 500 ml of isopropanol are added 60 ml of liquid ammonia and 6.8 g of Raney-Nickel. The mixture is heated to 80° and treated with hydrogen at 100 bar. After 11/2 hours hydrogen-uptake stops. The reaction mixture is filtered and the filtrate distilled to give isopropyl 3-aminopropyl(ethyl)phosphinate as a colorless oil, b.p. 75°/13 Pa.
Workup
- temperatureThe mixture is heated to 80°
- filtrationThe reaction mixture is filtered
- distillationthe filtrate distilled
Sources & evidence
- ORD record
- ord-d31ee94fbad84602802c0581b775044d
- Source dataset
- uspto-grants-1994_04
- Patent number
- US05300679
Reaction notes
Loading…