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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 14641Generated: October 26, 2026

Hydrochloric Acid → 1-Aminomethyl-6,8-dimethoxy-isoquinoline-4-carboxylic acid methyl-pyridin-3-ylmethyl-amide hydrochloride

https://huagongshe.com/reaction/14641

Reaction equation

Participants

RoleNameHCIDCharge
ReactantHydrochloric AcidHCID 313—
Reactant[6,8-Dimethoxy-4-(methyl-pyridin-3-ylmethyl-carbamoyl)-isoquinolin-1-ylmethyl]-carbamic acid tert-butyl esterHCID 68614078—
SolventEthyl AcetateHCID 8857—
Product1-Aminomethyl-6,8-dimethoxy-isoquinoline-4-carboxylic acid methyl-pyridin-3-ylmethyl-amide hydrochlorideHCID 68614784100%

Reaction Steps

As described in example 1, 88 mg of [6,8-dimethoxy-4-(methyl-pyridin-3-ylmethyl-carbamoyl)-isoquinolin-1-ylmethyl]-carbamic acid tert-butyl ester was treated with HCl in EtOAc to give 102 mg (>100%) of 1-aminomethyl-6,8-dimethoxy-isoquinoline-4-carboxylic acid methyl-pyridin-3-ylmethyl-amide hydrochloride. MS: APCI (M+H) calc'd for C21H24N4O3+H 381.4; found 381.2.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07732446B1
Source datasetuspto-grants-2010_06
ORD IDord-059fc9ff38c549f4a0ffff66bbb9d78d
Source noteuspto-grants-2010_06