Trifluoroacetic acid → HCID 89525152, compound
Reaction equation
[C:1]([C:3]1[CH:12]=[C:11]2[C:6]([CH:7]=[C:8]([N:13]3[CH2:18][CH2:17][N:16](C(OC(C)(C)C)=O)[CH2:15][C:14]3=[O:26])[CH:9]=[N:10]2)=[CH:5][CH:4]=1)#[N:2].C(O)(C(F)(F)F)=O>>[O:26]=[C:14]1[CH2:15][NH:16][CH2:17][CH2:18][N:13]1[C:8]1[CH:9]=[N:10][C:11]2[C:6]([CH:7]=1)=[CH:5][CH:4]=[C:3]([C:1]#[N:2])[CH:12]=2Participants
3
Procedure
tert-Butyl 4-(7-cyanoquinolin-3-yl)-3-oxopiperazine-1-carboxylate (0.030 g, 0.099 mmol) was treated with TFA (2 mL) and stirred for 20 minutes. Analysis of the reaction mixture by LC indicated that reaction had gone to completion. The solution was concentrated in vacuo and crude was azetroped with dichloroethane (3×8 mL) to furnish the title product. LC/MS (IE, m/z): [M+1]+=253.
Workup
- customAnalysis of the reaction mixture by LC indicated that reaction
- concentrationThe solution was concentrated in vacuo and crude