3-Fluoro-5-(4-methoxy-benzylsulfanyl)-benzoic acid ethyl ester → 3-Fluoro-5-mercapto-benzoic acid ethyl ester
Reaction equation
[CH2:1]([O:3][C:4](=[O:22])[C:5]1[CH:10]=[C:9]([S:11]CC2C=CC(OC)=CC=2)[CH:8]=[C:7]([F:21])[CH:6]=1)[CH3:2]>C(O)(C(F)(F)F)=O>[CH2:1]([O:3][C:4](=[O:22])[C:5]1[CH:10]=[C:9]([SH:11])[CH:8]=[C:7]([F:21])[CH:6]=1)[CH3:2]Participants
3
Reactant 1
Product 1
Reagents, catalysts & solvents 1
Procedure
3-Fluoro-5-(4-methoxy-benzylsulfanyl)-benzoic acid ethyl ester (7.24 g, 22.5 mmol)was stirred in TFA (10 mL) at 70° C. for overnight. The resulting mixture was cooled to room temperature and subjected to standard aqueous workup. The crude residue was purified on silica gel (0-30% EtOAc in hexanes) to afford the title compound.
Workup
- customThe crude residue was purified on silica gel (0-30% EtOAc in hexanes)
Sources & evidence
- ORD record
- ord-fb6a0a8e1ddf406087c3bb1518feae61
- Source dataset
- uspto-grants-2015_04
- Patent number
- US09000025B2
Reaction notes
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