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Potassium Carbonate → 7'-(5-Chloropyridin-3-yl)-5''-methyl-3',4'-dihydrodispiro[cyclopropane-1,2'-naphthalene-1',2''-imidazol]-4''-amine

HRID 1468237
Notes
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Reaction equation

HRID 1468237 reaction equation
Br[C:2]1[CH:19]=[C:18]2[C:5]([CH2:6][CH2:7][C:8]3([C:11]42[N:15]=[C:14]([NH2:16])[C:13]([CH3:17])=[N:12]4)[CH2:10][CH2:9]3)=[CH:4][CH:3]=1.[Cl:20][C:21]1[CH:22]=[C:23](B(O)O)[CH:24]=[N:25][CH:26]=1.C(=O)([O-])[O-].[K+].[K+].O1CCOCC1>C(Cl)Cl.C1C=CC(P(C2C=CC=CC=2)[C-]2C=CC=C2)=CC=1.C1C=CC(P(C2C=CC=CC=2)[C-]2C=CC=C2)=CC=1.Cl[Pd]Cl.[Fe+2]>[Cl:20][C:21]1[CH:22]=[C:23]([C:2]2[CH:19]=[C:18]3[C:5]([CH2:6][CH2:7][C:8]4([C:11]53[N:15]=[C:14]([NH2:16])[C:13]([CH3:17])=[N:12]5)[CH2:9][CH2:10]4)=[CH:4][CH:3]=2)[CH:24]=[N:25][CH:26]=1
ParticipantsConditionsProcedureWorkupSources & evidenceReaction notes

Participants

7

Reactant 4

HCID 11430Potassium CarbonateHCID 312751,4-DioxaneHCID 201118775-Chloropyridine-3-boronic acidHCID 727146587'-Bromo-5''-methyl-3',4'-dihydrodispiro[cyclopropane-1,2'-naphthalene-1',2''-imidazol]-4''-amine

Product 1

HCID 727147457'-(5-Chloropyridin-3-yl)-5''-methyl-3',4'-dihydrodispiro[cyclopropane-1,2'-naphthalene-1',2''-imidazol]-4''-amine
Yield 37.7%

Reagents, catalysts & solvents 2

HCID 44119782Bis(cyclopenta-1,4-dien-1-yl(diphenyl)phosphane);dichloropalladium;iron(2+)CatalystHCID 6344DichloromethaneSolvent

Conditions

Temperature
130 °C

Procedure

A mixture of 7′-bromo-5″-methyl-3′,4′-dihydrodispiro[cyclopropane-1,2′-naphthalene-1′,2″-imidazol]-4″-amine (Example 1, 100 mg, 0.31 mmol), 5-chloropyridin-3-ylboronic acid (74 mg, 0.47 mmol), [1,1′-bis(diphenylphosphino)ferrocene]palladium(II) chloride (23 mg, 0.03 mmol), aq. potassium carbonate (2 M, 0.31 mL, 0.63 mmol) and 1,4-dioxane (1 mL) were mixed in a vial and heated in a microwave reactor at 130° C. for 30 min. When cooled to r.t., the mixture was diluted with DCM, washed with water and dried over Na2SO4. The filtrate was concentrated and the product purified by preparative HPLC to give the title compound (41 mg, 37% yield). 1H NMR (500 MHz, DMSO-d6) δ ppm 0.10 (m, 2 H), 0.24 (m, 1 H), 0.55 (m, 1 H), 1.51 (dt, 1 H), 2.18 (s, 3 H), 2.39 (m, 1 H), 3.01 (m, 2 H), 6.52 (br. s., 2 H), 6.74 (d, 1 H), 7.30 (d, 1 H), 7.52 (dd, 1 H), 7.97 (s, 1 H), 8.57 (d, 1 H), 8.61 (d, 1 H); MS (APCI+) m/z 351 [M+H]+.

Workup

  1. additionwere mixed in a vial and
  2. temperatureWhen cooled to r.t.
  3. washwashed with water
  4. dry with materialdried over Na2SO4
  5. concentrationThe filtrate was concentrated
  6. customthe product purified by preparative HPLC

Sources & evidence

ORD record
ord-d83d89cefc884b7abcaee1662f3a7302
Source dataset
uspto-grants-2015_04
DOI
10.6084/m9.figshare.5104873.v1
Patent number
US09000184B2

Reaction notes

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On this pageParticipantsConditionsProcedureWorkupSources & evidenceReaction notes