Tetrahydrofuran → 1-(3-Fluoro-4-hydroxyphenyl)propan-1-one

HRID 147046

Reaction equation

HRID 147046 reaction equation
[Br:1][c:2]1[cH:3][c:4]([F:9])[c:5]([OH:8])[cH:6][cH:7]1.[CH3:15][N:16]([C:17]([CH2:18][CH3:19])=[O:20])[O:21][CH3:22].[Li:10][CH2:11][CH2:12][CH2:13][CH3:14].[O:23]1[CH2:24][CH2:25][CH2:26][CH2:27]1>>[c:2]1([C:17]([CH2:18][CH3:19])=[O:20])[cH:3][c:4]([F:9])[c:5]([OH:8])[cH:6][cH:7]1

Participants

5

Reactant 4

HCID 8028TetrahydrofuranHCID 27249814-Bromo-2-fluorophenolHCID 11344007N-Methoxy-N-methylpropionamideHCID 178418339Butyllithium

Product 1

HCID 133224411-(3-Fluoro-4-hydroxyphenyl)propan-1-one

Sources & evidence

ORD record
ord-40ba5e3e502243dabf65b8b55fcc6f3e
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Linked notes

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