Piperidine → (4-Methoxy-8-methylnaphthalen-1-yl)(piperidin-1-yl)methanone

Reaction equation

[CH3:1][O:2][C:3]1[C:12]2[C:7](=[C:8]([CH3:13])[CH:9]=[CH:10][CH:11]=2)[C:6]([C:14]([OH:16])=O)=[CH:5][CH:4]=1.[NH:17]1[CH2:22][CH2:21][CH2:20][CH2:19][CH2:18]1>>[CH3:1][O:2][C:3]1[C:12]2[C:7](=[C:8]([CH3:13])[CH:9]=[CH:10][CH:11]=2)[C:6]([C:14]([N:17]2[CH2:22][CH2:21][CH2:20][CH2:19][CH2:18]2)=[O:16])=[CH:5][CH:4]=1

Participants

Reactant 2

HCID 8082Piperidine

HCID 68282059HCID 68282059, compound

Product 1

HCID 68281933(4-Methoxy-8-methylnaphthalen-1-yl)(piperidin-1-yl)methanone

Procedure

4-Methoxy-8-methyl-1-naphthoic acid (Step-5 of Intermediate-22) was reacted with piperidine by following the similar procedure as described in Step-6 of Intermediate-22.

Sources & evidence

ORD record: ord-c78ad198ac524b13a33d2419c81ec068
Source dataset: uspto-grants-2015_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09006442B2

Reaction notes

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