2-Bromopyridine → HCID 68487935, compound

HRID 1474013

Reaction equation

HRID 1474013 reaction equation
Br[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][N:3]=1.[NH2:8][C:9]1[CH:16]=[CH:15][C:12]([C:13]#[N:14])=[C:11]([OH:17])[CH:10]=1>CCO>[C:13]([C:12]1[CH:15]=[CH:16][C:9]([NH:8][C:2]2[CH:7]=[CH:6][CH:5]=[CH:4][N:3]=2)=[CH:10][C:11]=1[OH:17])#[N:14]

Participants

4

Reactant 2

HCID 79732-BromopyridineHCID 124686824-Amino-2-hydroxybenzonitrile

Product 1

HCID 68487935HCID 68487935, compoundYield 1%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
90 °C

Procedure

Following the general procedure for the synthesis of 2-R-5-(heteroaryl-2-ylamino)phenol, 2-bromopyridine (0.21 mL, 2.2 mmol) and 4-amino-2-hydroxybenzonitrile (146 mg, 1.1 mmol) in 10% aqueous EtOH (5 mL) was heated at 90° C. for 18 h. The title compound was obtained after purification by flash chromatography on silica gel (hexane:EtOAc 1/1) in 1% yield (1.5 mg).

Sources & evidence

ORD record
ord-7c34079573b4431bb711db520a74b787
Source dataset
uspto-grants-2015_04
Patent number
US09018209B2

Linked notes

Loading…