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Hydrochloric Acid → 6-(2,3-difluorophenyl)-1-[(2-ethyl-2H-tetrazol-5-yl)methyl]-3-(piperidin-4-yl)thieno[3,2-d]pyrimidine-2,4(1H,3H)-dione hydrochloride

HRID 1476645
Notes
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Reaction equation

HRID 1476645 reaction equation
[F:1][C:2]1[C:7]([F:8])=[CH:6][CH:5]=[CH:4][C:3]=1[C:9]1[S:17][C:16]2[C:15](=[O:18])[N:14]([CH:19]3[CH2:24][CH2:23][N:22](C(OC(C)(C)C)=O)[CH2:21][CH2:20]3)[C:13](=[O:32])[N:12]([CH2:33][C:34]3[N:35]=[N:36][N:37]([CH2:39][CH3:40])[N:38]=3)[C:11]=2[CH:10]=1.[ClH:41]>O1CCOCC1>[ClH:41].[F:1][C:2]1[C:7]([F:8])=[CH:6][CH:5]=[CH:4][C:3]=1[C:9]1[S:17][C:16]2[C:15](=[O:18])[N:14]([CH:19]3[CH2:20][CH2:21][NH:22][CH2:23][CH2:24]3)[C:13](=[O:32])[N:12]([CH2:33][C:34]3[N:35]=[N:36][N:37]([CH2:39][CH3:40])[N:38]=3)[C:11]=2[CH:10]=1
ParticipantsProcedureSources & evidenceReaction notes

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 67257703tert-butyl 4-[6-(2,3-difluorophenyl)-1-[(2-ethyl-2H-tetrazol-5-yl)methyl]-2,4-dioxo-1,4-dihydrothieno[3,2-d]pyrimidin-3(2H)-yl]piperidine-1-carboxylate

Product 1

HCID 672581586-(2,3-difluorophenyl)-1-[(2-ethyl-2H-tetrazol-5-yl)methyl]-3-(piperidin-4-yl)thieno[3,2-d]pyrimidine-2,4(1H,3H)-dione hydrochloride

Reagents, catalysts & solvents 1

HCID 312751,4-Dioxane
Solvent
2×

Procedure

Tert-butyl 4-[6-(2,3-difluorophenyl)-1-[(2-ethyl-2H-tetrazol-5-yl)methyl]-2,4-dioxo-1,4-dihydrothieno[3,2-d]pyrimidin-3(2H)-yl]piperidine-1-carboxylate (44 mg, compound B61) and a solution of hydrogen chloride in 1,4-dioxane (0.2 ml+0.9 ml, 4.0 M) in 1,4 dioxane (2 ml) are reacted according to the procedure described in example B79 to afford the title compound.

Sources & evidence

ORD record
ord-6c59fa0e60ca40a583e9757fc82f536e
Source dataset
uspto-grants-2015_04
DOI
10.6084/m9.figshare.5104873.v1
Patent number
US09018175B2

Reaction notes

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On this pageParticipantsProcedureSources & evidenceReaction notes