Methane → HCID 178525362, compound
Reaction equation
C([N:8]1[CH:12]=[C:11]([CH2:13][CH2:14][C:15]([OH:17])=[O:16])[N:10]=[N:9]1)C1C=CC=CC=1.C>CCO>[NH:8]1[CH:12]=[C:11]([CH2:13][CH2:14][C:15]([OH:17])=[O:16])[N:10]=[N:9]1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
3-(1-Benzyl-1H-1,2,3-triazol-4-yl)propanoic acid (step 1) (4.37 g, 18.90 mmol) was dissolved in EtOH and stirred for 10 mins with activated charcoal (1.13 g) and of Celite® (filter material). The reaction mixture was filtered and transferred into a 400 mL Duran Bottle. The colorless solution was set on a continuous cycle at 30 bar pressure and 70° C. through the H-Cube (continuous flow hydrogenation) for 24 hrs. The resulting material was concentrated under reduced pressure and the crude product was suspended in ether and filtered to afford the title compound;
Workup
- filtrationThe reaction mixture was filtered
- concentrationThe resulting material was concentrated under reduced pressure
- filtrationfiltered
Sources & evidence
- ORD record
- ord-81d1f8268fd8447891891e03efa4ded0
- Source dataset
- uspto-grants-2016_08
- Patent number
- US09409895B2
Reaction notes
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