Methane → Tert-butyl 4-(4-amino-2-methylphenoxy)piperidine-1-carboxylate

Reaction equation

[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH2:10][CH:11]([O:14][c:15]2[c:16]([CH3:24])[cH:17][c:18]([N+:21]([O-:22])=[O:23])[cH:19][cH:20]2)[CH2:12][CH2:13]1.[C:28].[CH3:25][CH2:26][OH:27].[Pd:29]>>[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH2:10][CH:11]([O:14][c:15]2[c:16]([CH3:24])[cH:17][c:18]([NH2:21])[cH:19][cH:20]2)[CH2:12][CH2:13]1

Participants

Reactant 4

HCID 297Methane

HCID 702Ethanol

HCID 23938Palladium

HCID 22181075tert-Butyl 4-(2-methyl-4-nitrophenoxy)piperidine-1-carboxylate

Product 1

HCID 22181171Tert-butyl 4-(4-amino-2-methylphenoxy)piperidine-1-carboxylate

Sources & evidence

ORD record: ord-681fc8bef23a43848e2634912ea4e03b
Source dataset: Training data from https://doi.org/10.1039/C8SC04228D (9/10)
DOI: 10.1039/C8SC04228D

Reaction notes

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