3-Aminopyridine → [3-(2-Chloro-pyrimidin-4-yl)-benzyl]-pyridin-3-yl-amine
Reaction equation
[Cl:1][C:2]1[N:7]=[C:6]([C:8]2[CH:9]=[C:10]([CH:13]=[CH:14][CH:15]=2)[CH:11]=O)[CH:5]=[CH:4][N:3]=1.[NH2:16][C:17]1[CH:18]=[N:19][CH:20]=[CH:21][CH:22]=1>>[Cl:1][C:2]1[N:7]=[C:6]([C:8]2[CH:9]=[C:10]([CH:13]=[CH:14][CH:15]=2)[CH2:11][NH:16][C:17]2[CH:18]=[N:19][CH:20]=[CH:21][CH:22]=2)[CH:5]=[CH:4][N:3]=1Participants
3
Procedure
Intermediate 1 was coupled with 3-aminopyridine following procedure B. LC-MS showed the product had the expected M+H+ of 297.
Sources & evidence
- ORD record
- ord-1a26662e7b0f40a1998da26103818dae
- Source dataset
- uspto-grants-2010_06
- Patent number
- US07732444B2
Reaction notes
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