Dimethylformamide dimethyl acetal → (E)-1-(3-((tert-butyldimethylsilyloxy)methyl)pyridin-2-yl)-3-(dimethylamino)prop-2-en-1-one
Reaction equation
[Si:1]([O:8][CH2:9][C:10]1[C:11]([C:16](=[O:18])[CH3:17])=[N:12][CH:13]=[CH:14][CH:15]=1)([C:4]([CH3:7])([CH3:6])[CH3:5])([CH3:3])[CH3:2].CO[CH:21](OC)[N:22]([CH3:24])[CH3:23]>>[Si:1]([O:8][CH2:9][C:10]1[C:11]([C:16](=[O:18])/[CH:17]=[CH:21]/[N:22]([CH3:24])[CH3:23])=[N:12][CH:13]=[CH:14][CH:15]=1)([C:4]([CH3:7])([CH3:6])[CH3:5])([CH3:3])[CH3:2]Participants
3
Procedure
1-(3-((tert-butyldimethylsilyloxy)methyl)pyridin-2-yl)ethanone (10.8 g, 40.75 mmol) in dimethoxy-N,N-dimethylmethanamine (15.0 mL) was heated to reflux for 3 days. The mixture was concentrated and used for next step without further purification. MS (ESI) m/z 321.1 [M+H]+.
Workup
- temperatureto reflux for 3 days
- concentrationThe mixture was concentrated
- custom