Sulfuric Acid → 3-Ethynylbenzoic acid methyl ester

tert-Butyl 3-ethynylbenzoate (I17) (1.50 g, 9.37 mmol) was dissolved in dry DCM (70 mL) and TFA (35.9 mL, 468 mmol) was added carefully. The reaction was stirred at room temperature for 3 hours, concentrated in vacuo and toluene was added and then removed in vacuo to give a pale yellow solid. This material was dissolved in methanol (50 mL) and conc. H2SO4 (˜1 mL) was added and the resulting solution was stirred at 65° C. for 20 hours. Upon cooling to room temperature, the volatiles were removed in vacuo and the residue was diluted with EtOAc (200 mL) and sat. aq. NaHCO3 (100 mL) was added slowly. The layers were separated and the aqueous layer was extracted with EtOAc (200 mL), the organic layers were combined and washed with water (100 mL), brine (100 mL), dried (MgSO4), filtered and concentrated in vacuo to give the title compound (I31) (1.136 g, 96% yield over 2 steps) as a pale yellow solid; 1H NMR (400 MHz, CDCl3) δ 8.17 (t, J=1.5 Hz, 1H), 8.03-8.00 (m, 1H), 7.66 (dt, J=7.7, 1.4 Hz, 1H), 7.41 (td, J=7.8, 0.4 Hz, 1H), 3.93 (s, 3H), 3.12 (s, 1H). LCMS Method C: rt 5.84 min.

1. concentrationconcentrated in vacuo and toluene
2. additionwas added
3. customremoved in vacuo
4. customto give a pale yellow solid
5. stirringthe resulting solution was stirred at 65° C. for 20 hours
6. temperatureUpon cooling to room temperature
7. customthe volatiles were removed in vacuo
8. additionthe residue was diluted with EtOAc (200 mL) and sat. aq. NaHCO3 (100 mL)
9. additionwas added slowly
10. customThe layers were separated
11. extractionthe aqueous layer was extracted with EtOAc (200 mL)
12. washwashed with water (100 mL), brine (100 mL)
13. dry with materialdried (MgSO4)
14. filtrationfiltered
15. concentrationconcentrated in vacuo

ORD record

ord-f3fde9670b194de1b8c58a5bf08ae6e2

Source dataset

uspto-grants-2016_08

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US09421205B2