2-Morpholinoethylamine → N4-benzyl-N2-(2-morpholinoethyl)-7-vinylthieno[3,2-d]pyrimidin-2,4-diamine
Reaction equation
[CH2:1]([NH:8][C:9]1[C:10]2[S:18][CH:17]=[C:16]([CH:19]=[CH2:20])[C:11]=2[N:12]=[C:13](Cl)[N:14]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[O:21]1[CH2:26][CH2:25][N:24]([CH2:27][CH2:28][NH2:29])[CH2:23][CH2:22]1>>[CH2:1]([NH:8][C:9]1[C:10]2[S:18][CH:17]=[C:16]([CH:19]=[CH2:20])[C:11]=2[N:12]=[C:13]([NH:29][CH2:28][CH2:27][N:24]2[CH2:25][CH2:26][O:21][CH2:22][CH2:23]2)[N:14]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1Participants
3
Procedure
The target compound of Example 46 (36 mg, 78% yield) was prepared in the same manner as Step 3 of Example 44 using N-benzyl-2-chloro-7-vinylthieno[3,2-d]pyrimidin-4-amine (35 mg, 0.116 mmol) and 2-morpholinoethanamine (75 mg, 0.58 mmol).
Sources & evidence
- ORD record
- ord-e80ae00df12e44f8a4c7e3e14f82bc54
- Source dataset
- uspto-grants-2016_08
- DOI