2,4-Dichloropyrimidine → 5-(2-Chloro-pyrimidin-4-yl)-2-fluoro-benzaldehyde

HRID 14869Notes

Reaction equation

HRID 14869 reaction equation
[Cl:1][C:2]1[N:7]=[C:6](Cl)[CH:5]=[CH:4][N:3]=1.[CH:9]([C:11]1[CH:12]=[C:13](B(O)O)[CH:14]=[CH:15][C:16]=1[F:17])=[O:10]>>[Cl:1][C:2]1[N:7]=[C:6]([C:13]2[CH:14]=[CH:15][C:16]([F:17])=[C:11]([CH:12]=2)[CH:9]=[O:10])[CH:5]=[CH:4][N:3]=1

Participants

3

Reactant 2

HCID 775312,4-DichloropyrimidineHCID 2778651(4-Fluoro-3-formylphenyl)boronic acid

Product 1

HCID 249019815-(2-Chloro-pyrimidin-4-yl)-2-fluoro-benzaldehyde

Procedure

2,4 dichloropyrimidine and 3-formyl 4-fluorophenyl boronic acid were coupled following procedure A. LC-MS showed the product was >95% pure and had the expected M+H+ of 237.

Sources & evidence

ORD record
ord-2bd34075cc684e6fa94351af2d25ceae
Source dataset
uspto-grants-2010_06
Patent number
US07732444B2

Reaction notes

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