Isopropylamine → HCID 90161040, compound
Reaction equation
[Br:1][C:2]1[N:3]=[C:4](Cl)[C:5]2[N:6]([C:8]([CH3:11])=[N:9][N:10]=2)[CH:7]=1.[CH:13]([NH2:16])([CH3:15])[CH3:14]>CN1C(=O)CCC1.O>[Br:1][C:2]1[N:3]=[C:4]([NH:16][CH:13]([CH3:15])[CH3:14])[C:5]2[N:6]([C:8]([CH3:11])=[N:9][N:10]=2)[CH:7]=1Participants
5
Reactant 2
Product 1
Reagents, catalysts & solvents 2
Conditions
- Temperature
- 80 °C
Procedure
6-bromo-8-chloro-3-methyl-[1,2,4]triazolo[4,3-a]pyrazine J-1 (30.00 g; 121.2 mmol), isopropylamine (14.30 g; 242.44 mmol) and hünigbase (17.20 g; 133.33 mmol) are dissolved in 150 ml NMP and are stirred for 2 hours at 80° C. The reaction mixture is diluted with water and extracted with EtOAc. The organic layer is separated and dried over MgSO4 and evaporated to dryness.
Workup
- extractionextracted with EtOAc
- customThe organic layer is separated
- dry with materialdried over MgSO4
- customevaporated to dryness
Sources & evidence
- ORD record
- ord-7625714b3e724b45b64374ae5950ddaa
- Source dataset
- uspto-grants-2016_08
- Patent number
- US09428513B2
Reaction notes
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