Pyrrolidine → 6-(Pyrrolidin-1-YL)pyridine-3,4-diamine

Reaction equation

[N:1]1([C:7]2[CH:12]=[C:11]([NH2:13])[C:10]([N+:14]([O-])=O)=[CH:9][N:8]=2)[CH2:6][CH2:5]O[CH2:3][CH2:2]1.N1CCCC1>>[N:1]1([C:7]2[N:8]=[CH:9][C:10]([NH2:14])=[C:11]([NH2:13])[CH:12]=2)[CH2:6][CH2:5][CH2:3][CH2:2]1

Participants

Reactant 2

HCID 31268Pyrrolidine

HCID 900216182-(Morpholin-4-yl)-5-nitropyridin-4-amine

Product 1

HCID 682882956-(Pyrrolidin-1-YL)pyridine-3,4-diamine

Procedure

The title compound was prepared using standard chemical manipulations and procedures similar to those used for the preparation of compound 151.1 and 151.2, except pyrrolidine was used in place of morpholine.

Sources & evidence

ORD record: ord-2fb64cc2060445a4ace0f83840de8698
Source dataset: uspto-grants-2016_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09428502B2

Reaction notes

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