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2,2-dimethyl-N-[2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl]butanamide → HCID 178442030, compound

HRID 1491092
Notes
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Reaction equation

HRID 1491092 reaction equation
CCC(C)(C)C(=O)Nc1c(F)c(F)c(C(F)(F)F)c(F)c1F>CC#N.CC(=O)O.CC(=O)O.CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.CC[N+](CC)(CC)CC.COc1cc(OC)c2ccccc2n1.F[B-](F)(F)F.O=C(O)O.[K].[Pd]>CCC(C)(CB1OC(C)(C)C(C)(C)O1)C(=O)Nc1c(F)c(F)c(C(F)(F)F)c(F)c1F
ParticipantsConditionsSources & evidenceReaction notes

Participants

9

Reactant 1

HCID 1350767852,2-dimethyl-N-[2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl]butanamide

Product 1

HCID 178442030HCID 178442030, compoundYield 73%

Reagents, catalysts & solvents 7

HCID 176Acetic AcidReagentHCID 1424362,4-DimethoxyquinolineReagentHCID 2724277Tetraethylammonium tetrafluoroborateReagentHCID 2733548Bis(pinacolato)diboraneReagentHCID 45051578carbonic acid, potassium saltReagentHCID 58759193palladium(I) acetateCatalystHCID 6342AcetonitrileSolvent

Conditions

Temperature
80 °C

Sources & evidence

ORD record
ord-7112c3b5b6fa4aaf81fcc5e5635f5a5a
Source dataset
Borylation dataset from Roche
DOI
10.1002/anie.201509996

Reaction notes

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On this pageParticipantsConditionsSources & evidenceReaction notes