Hydrochloric Acid → 5H,6H,7H-pyrrolo(3,4-b)pyridine dihydrochloride

Reaction equation

[NH:1]1[CH2:6][CH:5]=[CH:4][C:3]2[CH2:7][N:8](C(OCC)=O)[CH2:9][C:2]1=2.[ClH:15]>>[ClH:15].[ClH:15].[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]2[CH2:7][NH:8][CH2:9][C:2]=12

Participants

Reactant 2

HCID 313Hydrochloric Acid

HCID 18953638HCID 18953638, compound

Product 1

HCID 235036165H,6H,7H-pyrrolo(3,4-b)pyridine dihydrochloride

Procedure

8.5 g (44 mmol) of ethyl 5,7-dihydro-1H-pyrrolo-[3,4-b]pyridine-6-carboxylate are refluxed overnight in 90 ml of concentrated hydrochloric acid. The solution is concentrated, the residue is stirred with acetone, and the salt is filtered off with suction and dried in the air.

Workup

concentrationThe solution is concentrated
filtrationthe salt is filtered off with suction
customdried in the air

Sources & evidence

ORD record: ord-52bf2b0ac6c541af9ab63afe10e76a1a
Source dataset: uspto-grants-1994_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05371090

Reaction notes

Loading…