Ammonium Hydroxide → 5-(4-Chlorophenyl)furan-2-carboxamide

HRID 1493760

Reaction equation

HRID 1493760 reaction equation
[NH4+:1].[OH-].[Cl:3][C:4]1[CH:9]=[CH:8][C:7]([C:10]2[O:14][C:13]([C:15](Cl)=[O:16])=[CH:12][CH:11]=2)=[CH:6][CH:5]=1>>[Cl:3][C:4]1[CH:9]=[CH:8][C:7]([C:10]2[O:14][C:13]([C:15]([NH2:1])=[O:16])=[CH:12][CH:11]=2)=[CH:6][CH:5]=1

Participants

3

Reactant 2

HCID 14923Ammonium HydroxideHCID 27719705-(4-chlorophenyl)furan-2-carbonyl Chloride

Product 1

HCID 47800015-(4-Chlorophenyl)furan-2-carboxamide

Procedure

To 1000 ml. of cold, stirring NH4OH, 63 g. (0.26 mole) of 5-(p-chlorophenyl)-2-furoyl chloride is added portionwise. The resulting mixture is stirred at ice bath temperature for 15 minutes and then is stored at room temperature for 18 hours. The solid is filtered, is washed with water and is dried at 60° to yield 56 g. (97%).

Workup

  1. waitis stored at room temperature for 18 hours
  2. filtrationThe solid is filtered
  3. washis washed with water
  4. customis dried at 60°
  5. customto yield 56 g

Sources & evidence

ORD record
ord-2245ed9770494de7b665cb3ba76866c2
Source dataset
uspto-grants-1991_06
Patent number
US05023272

Linked notes

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