Hydrochloric Acid → 1-(1-Benzothiophen-4-yl)piperazine hydrochloride
Reaction equation
[ClH:1].[S:2]1[CH:6]=[CH:5][C:4]2[C:7]([N:11]3[CH2:16][CH2:15][NH:14][CH2:13][CH2:12]3)=[CH:8][CH:9]=[CH:10][C:3]1=2>CO>[ClH:1].[S:2]1[CH:6]=[CH:5][C:4]2[C:7]([N:11]3[CH2:16][CH2:15][NH:14][CH2:13][CH2:12]3)=[CH:8][CH:9]=[CH:10][C:3]1=2Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
3.7 ml of concentrated hydrochloric acid was added to a methanol solution of 9.5 g of 1-benzo[b]thiophen-4-yl-piperazine, and the solvent was evaporated under reduced pressure. Ethyl acetate was added to the residue and precipitated crystals were filtrated and recrystallized from methanol and 1-benzo[b]thiophen-4-yl-piperazine hydrochloride was obtained as colorless needle-like crystals.
Workup
- customthe solvent was evaporated under reduced pressure
- additionEthyl acetate was added to the residue
- customprecipitated crystals
- filtrationwere filtrated
- customrecrystallized from methanol
Sources & evidence
- ORD record
- ord-e23b946abf22472783ad19580957631e
- Source dataset
- uspto-grants-2015_12
- Patent number
- US09206167B2
Reaction notes
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