1,4-Butanediol → Tert-butyl 2-(4-hydroxybutoxymethyl)-6-methylbenzoate

HRID 15095

Reaction equation

HRID 15095 reaction equation
Br[CH2:2][C:3]1[CH:15]=[CH:14][CH:13]=[C:12]([CH3:16])[C:4]=1[C:5]([O:7][C:8]([CH3:11])([CH3:10])[CH3:9])=[O:6].[CH2:17]([OH:22])[CH2:18][CH2:19][CH2:20][OH:21].OCCCOCC1C=CC=C(C)C=1C(OC(C)(C)C)=O>>[OH:21][CH2:20][CH2:19][CH2:18][CH2:17][O:22][CH2:2][C:3]1[CH:15]=[CH:14][CH:13]=[C:12]([CH3:16])[C:4]=1[C:5]([O:7][C:8]([CH3:11])([CH3:10])[CH3:9])=[O:6]

Participants

4

Reactant 3

HCID 80641,4-ButanediolHCID 59341259Tert-butyl 2-(3-hydroxypropoxymethyl)-6-methylbenzoateHCID 59341261tert-Butyl 2-(bromomethyl)-6-methylbenzoate

Product 1

HCID 59341263Tert-butyl 2-(4-hydroxybutoxymethyl)-6-methylbenzoate

Procedure

tert-Butyl 2-(4-hydroxybutoxymethyl)-6-methylbenzoate is prepared from tert-butyl 2-bromomethyl-6-methylbenzoate and butane-1,4-diol in analogy to the synthesis of tert-butyl 2-(3-hydroxypropoxymethyl)-6-methylbenzoate.

Sources & evidence

ORD record
ord-a3f13bbb3b6247e4939028582f7ce2db
Source dataset
uspto-grants-2010_06
Patent number
US07732471B2

Linked notes

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