Hydrochloric Acid → 2,2-Dimethyl-propionic acid (R)-2-amino-3-(4-methoxy-benzylsulfanyl)-propyl ester
Reaction equation
C(OC([NH:8][C@H:9]([CH2:12][S:13][CH2:14][C:15]1[CH:20]=[CH:19][C:18]([O:21][CH3:22])=[CH:17][CH:16]=1)[CH2:10][OH:11])=O)(C)(C)C.[CH3:23][C:24]([CH3:29])([CH3:28])[C:25](Cl)=[O:26].Cl>>[NH2:8][C@@H:9]([CH2:12][S:13][CH2:14][C:15]1[CH:16]=[CH:17][C:18]([O:21][CH3:22])=[CH:19][CH:20]=1)[CH2:10][O:11][C:25](=[O:26])[C:24]([CH3:29])([CH3:28])[CH3:23]Participants
4
Procedure
(S)-2-t-butoxycarbonylamino-3-(4-methoxy-benzylsulfanyl)-propanol prepared in Step C, trimethylacetylchloride and HCl (4 N dioxane solution) were reacted according to the same procedures as Steps D and E of Preparation 31 consecutively to give the title compound.