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Hydrochloric Acid → Hydrochloric Acid

HRID 1516530
Notes
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Reaction equation

HRID 1516530 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][CH2:11][CH:10]([C:14]2[S:15][CH:16]=[C:17]([CH2:19][O:20][C:21]3[CH:26]=[CH:25][C:24]([N:27]4[CH:31]=[N:30][N:29]=[N:28]4)=[CH:23][CH:22]=3)[N:18]=2)[CH2:9]1)=O)(C)(C)C.[ClH:32]>ClCCl.CO.O1CCOCC1>[N:27]1([C:24]2[CH:23]=[CH:22][C:21]([O:20][CH2:19][C:17]3[N:18]=[C:14]([CH:10]4[CH2:11][CH2:12][CH2:13][NH:8][CH2:9]4)[S:15][CH:16]=3)=[CH:26][CH:25]=2)[CH:31]=[N:30][N:29]=[N:28]1.[ClH:32]
ParticipantsProcedureWorkupSources & evidenceReaction notes

Participants

7

Reactant 2

HCID 313Hydrochloric AcidHCID 57986828HCID 57986828, compound

Product 2

HCID 313Hydrochloric AcidHCID 57473380HCID 57473380, compound

Reagents, catalysts & solvents 3

HCID 887MethanolSolventHCID 6344DichloromethaneSolvent
HCID 31275
1,4-Dioxane
Solvent

Procedure

A solution of 3-[4-(4-Tetrazol-1-yl-phenoxymethyl)-thiazol-2-yl]-piperidine-1-carboxylic acid tert-butyl ester (500 mg, 1.13 mmol) in dichloromethane (10 mL) and methanol (2 mL) were treated with 2 mL of 4N HCl in dioxane. The resulting solution was stirred at room temperature for 30 minutes. The solvents were removed in vacuo to afford the desired product as an HCl salt.

Workup

  1. customThe solvents were removed in vacuo

Sources & evidence

ORD record
ord-fe344a447e864d05a017e562bceacf7a
Source dataset
uspto-grants-2012_07
DOI
10.6084/m9.figshare.5104873.v1
Patent number
US08227495B2

Reaction notes

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On this pageParticipantsProcedureWorkupSources & evidenceReaction notes