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4-Chloro-3-nitrobenzenesulfonamide → HCID 67126605, compound

HRID 1520609
Notes
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Reaction equation

HRID 1520609 reaction equation
Cl[C:2]1[CH:7]=[CH:6][C:5]([S:8]([NH2:11])(=[O:10])=[O:9])=[CH:4][C:3]=1[N+:12]([O-:14])=[O:13].Cl.Cl.[NH2:17][CH2:18][C:19]1([NH2:25])[CH2:24][CH2:23][O:22][CH2:21][CH2:20]1.C(N(CC)CC)C>O1CCOCC1.O>[NH2:25][C:19]1([CH2:18][NH:17][C:2]2[CH:7]=[CH:6][C:5]([S:8]([NH2:11])(=[O:10])=[O:9])=[CH:4][C:3]=2[N+:12]([O-:14])=[O:13])[CH2:24][CH2:23][O:22][CH2:21][CH2:20]1
ParticipantsConditionsProcedureWorkupSources & evidenceReaction notes

Participants

6

Reactant 3

HCID 73244-Chloro-3-nitrobenzenesulfonamideHCID 8471TriethylamineHCID 67227314HCID 67227314, compound

Product 1

HCID 67126605HCID 67126605, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 312751,4-Dioxane
Solvent

Conditions

Temperature
110 °C

Procedure

A mixture of 4-chloro-3-nitrobenzenesulfonamide, 4-(aminomethyl)tetrahydro-2H-pyran-4-amine bis-hydrochloric acid salt and triethylamine in dioxane (10 mL) was heated at 110° C. overnight. After cooling, the reaction mixture was diluted with water (10 mL), and the solid was filtered to give the title compound.

Workup

  1. temperatureAfter cooling
  2. filtrationthe solid was filtered

Sources & evidence

ORD record
ord-cf459217b39b4f379a19a5d8f561d259
Source dataset
uspto-grants-2015_07
DOI
10.6084/m9.figshare.5104873.v1
Patent number
US09073855B2

Reaction notes

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On this pageParticipantsConditionsProcedureWorkupSources & evidenceReaction notes