Hydrogen Bromide → (R)-3-(3,4-Dihydroxyphenyl)-2-propylamine hydrobromide

Reaction equation

C[O:2][C:3]1[CH:4]=[C:5]([CH2:11][C@H:12]([NH2:14])[CH3:13])[CH:6]=[CH:7][C:8]=1[O:9]C.[BrH:15]>>[BrH:15].[OH:2][C:3]1[CH:4]=[C:5]([CH2:11][C@H:12]([NH2:14])[CH3:13])[CH:6]=[CH:7][C:8]=1[OH:9]

Participants

Reactant 2

HCID 260Hydrogen Bromide

HCID 117694083,4-Dma, (R)-

Product 1

HCID 67643451(R)-3-(3,4-Dihydroxyphenyl)-2-propylamine hydrobromide

Procedure

A solution of (R)-3-(3,4-dimethoxyphenyl)-2-propylamine hydrochloride1 (500 mg, 2.15 mMol) in hydrogen bromide (48%, 5 ml) was stirred at 100° C. under an argon atmosphere for 20 hours. After cooling, the solvent was evaporated and the residue was dried giving the title compound.

Workup

temperatureAfter cooling
customthe solvent was evaporated
customthe residue was dried

Sources & evidence

ORD record: ord-a3c93df638364213adea34d2adfb06d5
Source dataset: uspto-grants-1998_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05726165

Reaction notes

Loading…