Trifluoroacetic acid → (3-Acetyl-6-amino-pyrrolo[2,3-b]pyridin-1-yl)-acetic acid trifluoroacetate
Reaction equation
C([O:5][C:6](=[O:30])[CH2:7][N:8]1[C:12]2=[N:13][C:14]([NH:17]CC3C=CC(OC)=CC=3)=[CH:15][CH:16]=[C:11]2[C:10]([C:27](=[O:29])[CH3:28])=[CH:9]1)(C)(C)C.[C:31]([OH:37])([C:33]([F:36])([F:35])[F:34])=[O:32]>C(Cl)Cl>[F:34][C:33]([F:36])([F:35])[C:31]([OH:37])=[O:32].[C:27]([C:10]1[C:11]2[C:12](=[N:13][C:14]([NH2:17])=[CH:15][CH:16]=2)[N:8]([CH2:7][C:6]([OH:30])=[O:5])[CH:9]=1)(=[O:29])[CH3:28]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
A solution of [3-acetyl-6-(4-methoxy-benzylamino)-pyrrolo[2,3-b]pyridin-1-yl]-acetic acid tert-butyl ester (51 mg, 0.125 mmol) and TFA (191 μL, 2.49 mmol) in CH2Cl2 (0.6 mL) was stirred at RT for 24 h. Volatils were removed under reduced pressure and the brown solid thus obtained was used without further purification in the next step. MS (UPLC/MS): 234.1 [M+H]+, 232.1 [M−H]−. 1H-NMR (400 MHz, DMSO): δ (ppm): 8.08 (d, 1H), 8.02 (s, 1H), 6.83 (m, 2H), 6.44 (d, 1H), 4.90 (s, 2H), 2.38 (s, 3H).