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Potassium Carbonate → HCID 90410457, compound

HRID 1527751
Notes
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Reaction equation

HRID 1527751 reaction equation
F[C:2]1[CH:3]=[C:4]([CH:13]=[CH:14][C:15]=1[N+:16]([O-:18])=[O:17])[O:5][CH2:6][C:7]1[CH:11]=[CH:10][N:9]([CH3:12])[N:8]=1.C([O-])([O-])=O.[K+].[K+].[CH3:25][C:26]1[CH:31]=[C:30]([O:32][C:33]([F:36])([F:35])[F:34])[CH:29]=[CH:28][C:27]=1[CH2:37][NH2:38]>C(#N)C>[CH3:12][N:9]1[CH:10]=[CH:11][C:7]([CH2:6][O:5][C:4]2[CH:13]=[CH:14][C:15]([N+:16]([O-:18])=[O:17])=[C:2]([CH:3]=2)[NH:38][CH2:37][C:27]2[CH:28]=[CH:29][C:30]([O:32][C:33]([F:34])([F:35])[F:36])=[CH:31][C:26]=2[CH3:25])=[N:8]1
ParticipantsConditionsProcedureWorkupSources & evidenceReaction notes

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 577941232-Methyl-4-(trifluoromethoxy)benzylamineHCID 828819703-((3-Fluoro-4-nitrophenoxy)methyl)-1-methyl-1H-pyrazole

Product 1

HCID 90410457HCID 90410457, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Conditions

Temperature
90 °C

Procedure

To a solution of 3-((3-fluoro-4-nitrophenoxy)methyl)-1-methyl-1H-pyrazole (143 mg, 0.573 mmol) in acetonitrile (10 mL) was added K2CO3 (317 mg, 2.3 mmol) followed by (2-methyl-4-(trifluoromethoxy)phenyl)methanamine (117 mg, 0.573 mmol). The mixture was stirred at 90° Celsius overnight. The reaction was cooled to RT and concentrated to dryness. The resulting residue was dissolved in DCM (50 mL) and washed with water (50 mL). The organic phase was concentrated to give the title compound. MS (ESI): mass calcd. for C20H19F3N4O4, 436.14; m/z found, 437 [M+H]+.

Workup

  1. temperatureThe reaction was cooled to RT
  2. concentrationconcentrated to dryness
  3. dissolutionThe resulting residue was dissolved in DCM (50 mL)
  4. washwashed with water (50 mL)
  5. concentrationThe organic phase was concentrated

Sources & evidence

ORD record
ord-0fbef858a0634cc7881ad70b9ca93086
Source dataset
uspto-grants-2015_07
DOI
10.6084/m9.figshare.5104873.v1
Patent number
US09089569B2

Reaction notes

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On this pageParticipantsConditionsProcedureWorkupSources & evidenceReaction notes