Bromomethylcyclopropane → (6-Chloro-4-iodo-5-cyclopropylmethoxy-pyridin-2-yl)-methanol

Reaction equation

[Cl:1][C:2]1[N:7]=[C:6]([CH2:8][OH:9])[CH:5]=[C:4]([I:10])[C:3]=1[OH:11].[CH:12]1([CH2:15]Br)[CH2:14][CH2:13]1>>[Cl:1][C:2]1[N:7]=[C:6]([CH2:8][OH:9])[CH:5]=[C:4]([I:10])[C:3]=1[O:11][CH2:15][CH:12]1[CH2:14][CH2:13]1

Participants

Reactant 2

HCID 81503Bromomethylcyclopropane

HCID 106845682-Chloro-6-(hydroxymethyl)-4-iodo-3-pyridinol

Product 1

HCID 86663132(6-Chloro-4-iodo-5-cyclopropylmethoxy-pyridin-2-yl)-methanol

Procedure

The title compound was synthesized in analogy to Example A, using 6-chloro-5-hydroxy-4-iodo-2-pyridinemethanol and cyclopropylmethyl bromide as starting materials; LC-MS (UV peak area/ESI) 95.8%, 339.9584 (M+H)+.

Sources & evidence

ORD record: ord-3a25f237dab3439387ee81c233c7e132
Source dataset: uspto-grants-2015_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09090599B2

Reaction notes

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