Ethanolamine → 3-[(2-Hydroxyethyl)amino]butanoic acid
Reaction equation
[C:1]([OH:6])(=[O:5])/[CH:2]=[CH:3]/[CH3:4].[CH2:7]([CH2:9][NH2:10])[OH:8]>N1C=CC=CC=1>[OH:8][CH2:7][CH2:9][NH:10][CH:3]([CH3:4])[CH2:2][C:1]([OH:6])=[O:5]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
A solution of 86 g of crotonic acid (1 mole) and ethanolamine (1 mole) in pyridine (200 ml) was refluxed for 2-3 hours and subsequently cooled. The resulting product was filtered and recyrstallized to yield the title compound having a m.p. (melting point) of 178-180° C. (compound 1.1, List of Compounds).
Workup
- temperaturesubsequently cooled
- filtrationThe resulting product was filtered
Sources & evidence
- ORD record
- ord-debaff6b009e4b08829fa69e98a3e7ea
- Source dataset
- uspto-grants-2001_03
- Patent number
- US06201023B1
Reaction notes
Loading…