HCID 178459173, compound → HCID 10036866, compound
Reaction equation
[C:1]([C:5](=[CH:10][NH:11][C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=1[O:18][CH3:19])[C:6]([O:8]C)=O)(=[O:4])[CH2:2][CH3:3]>C1(OC2C=CC=CC=2)C=CC=CC=1>[C:1]([C:5]1[C:6](=[O:8])[C:17]2[C:12](=[C:13]([O:18][CH3:19])[CH:14]=[CH:15][CH:16]=2)[NH:11][CH:10]=1)(=[O:4])[CH2:2][CH3:3]Participants
3
Reactant 1
Product 1
Reagents, catalysts & solvents 1
Procedure
Methyl 2-propanoyl-3-(2-methoxyphenylamino)acrylate (77.7 g, 0.29 mol) was added to boiling diphenyl ether (500 ml) then heated at reflux for 1 hour. The solution was partially cooled and poured into high-boiling petroleum ether, then the solid filtered off and washed with 40-60 petroleum ether to give 3-propanoyl-8-methoxy-4(1H)-quinolone (35.6 g, 52%), m.p. 260°-263°.
Workup
- temperaturethen heated
- temperatureat reflux for 1 hour
- temperatureThe solution was partially cooled