Hydrogen Bromide → HCID 19908238, compound

Reaction equation

C1(C)C=CC(S([N:10]2[CH2:18][C:17]3[CH2:16][NH:15][CH2:14][CH2:13][C:12]=3[CH2:11]2)(=O)=O)=CC=1.O.[BrH:21]>C1(O)C=CC=CC=1>[BrH:21].[BrH:21].[C:17]12[CH2:18][NH:10][CH2:11][C:12]=1[CH2:13][CH2:14][NH:15][CH2:16]2

Participants

Procedure

1.5 g of N8 -(p-toluenesulfonyl)-3,8-diazabicyclo[4.3.0]non-1(6)-ene, prepared in Preparation 8, was suspended in 15 ml of 48% hydrobromic acid and 2 g of phenol, and the reaction mixture was refluxed for 4 hours. After cooling the reaction mixture, 20 ml of water was added. The mixture was washed with chloroform (40 ml×3). The aqueous phase was taken and decolorized by active carbon. The aqueous phase was concentrated under reduced pressure and thus resulting solid was washed with 1:1 methanol-ethylether solvent. 0.9 g of the title compound was obtained (yield 98%).