Dichloromethane → 3-chloro-4-fluoro-N-[4-(4-iodo-phenyl)-piperidin-4-ylmethyl]-benzenesulfonamide

HRID 1536935Notes

Reaction equation

HRID 1536935 reaction equation
[C:1]([O:2][C:3](=[O:4])[N:8]1[CH2:9][CH2:10][C:11]([c:14]2[cH:15][cH:16][c:17]([I:20])[cH:18][cH:19]2)([CH2:21][NH:22][S:23](=[O:24])(=[O:25])[c:26]2[cH:27][c:28]([Cl:33])[c:29]([F:32])[cH:30][cH:31]2)[CH2:12][CH2:13]1)([CH3:5])([CH3:6])[CH3:7].[Cl:41][CH2:42][Cl:43].[F:34][C:35]([F:36])([F:37])[C:38]([OH:39])=[O:40]>>[NH:8]1[CH2:9][CH2:10][C:11]([c:14]2[cH:15][cH:16][c:17]([I:20])[cH:18][cH:19]2)([CH2:21][NH:22][S:23](=[O:24])(=[O:25])[c:26]2[cH:27][c:28]([Cl:33])[c:29]([F:32])[cH:30][cH:31]2)[CH2:12][CH2:13]1

Participants

4

Reactant 3

HCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 685333514-[(3-Chloro-4-fluoro-benzenesulfonylamino)-methyl]-4-(4-iodo-phenyl)-piperidine-1-carboxylic acid tert-butyl ester

Product 1

HCID 224903833-chloro-4-fluoro-N-[4-(4-iodo-phenyl)-piperidin-4-ylmethyl]-benzenesulfonamide

Sources & evidence

ORD record
ord-f792bfe30253434ca5ff13f28d7df977
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (1/10)

Reaction notes

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