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Tetrahydrofuran → 2,2,2-Trifluoro-1-(4-fluoro-phenyl)-1-[4-(1,1,1,3,3,3-hexamethyl disilazan-2-yl)-3,5-dimethyl-phenyl]-ethanol

HRID 1541496
Notes
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Reaction equation

HRID 1541496 reaction equation
[Br:1][c:2]1[cH:3][c:4]([CH3:18])[c:5]([N:9]([Si:10]([CH3:11])([CH3:12])[CH3:13])[Si:14]([CH3:15])([CH3:16])[CH3:17])[c:6]([CH3:8])[cH:7]1.[CH2:19]([Li:20])[CH2:21][CH2:22][CH3:23].[F:24][C:25]([C:26](=[O:27])[c:28]1[cH:29][cH:30][c:31]([F:34])[cH:32][cH:33]1)([F:35])[F:36].[O:37]1[CH2:38][CH2:39][CH2:40][CH2:41]1>>[c:2]1([C:26]([C:25]([F:24])([F:35])[F:36])([OH:27])[c:28]2[cH:29][cH:30][c:31]([F:34])[cH:32][cH:33]2)[cH:3][c:4]([CH3:18])[c:5]([N:9]([Si:10]([CH3:11])([CH3:12])[CH3:13])[Si:14]([CH3:15])([CH3:16])[CH3:17])[c:6]([CH3:8])[cH:7]1
ParticipantsSources & evidenceReaction notes

Participants

5

Reactant 4

HCID 8028TetrahydrofuranHCID 695642,2,2,4'-TetrafluoroacetophenoneHCID 594978222-(4-Bromo-2,6-dimethyl-phenyl)-1,1,1,3,3,3-hexamethyl-disilazaneHCID 178418339Butyllithium

Product 1

HCID 594978232,2,2-Trifluoro-1-(4-fluoro-phenyl)-1-[4-(1,1,1,3,3,3-hexamethyl disilazan-2-yl)-3,5-dimethyl-phenyl]-ethanol

Sources & evidence

ORD record
ord-3e802e8404e7406fb78e47eed5d05110
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (1/10)
DOI
10.1039/C8SC04228D

Reaction notes

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On this pageParticipantsSources & evidenceReaction notes