N,N-Dimethylaniline → 7-Chloro-5-(tetrahydro-2H-thiopyran-4-yl)pyrazolo[1,5-a]pyrimidine

Reaction equation

[CH3:17][N:18]([CH3:19])[c:20]1[cH:21][cH:22][cH:23][cH:24][cH:25]1.[Cl:26][P:27](=[O:28])([Cl:29])[Cl:30].[S:1]1[CH2:2][CH2:3][CH:4]([c:7]2[n:8][c:9]3[n:10]([c:11]([OH:13])[cH:12]2)[n:14][cH:15][cH:16]3)[CH2:5][CH2:6]1>>[S:1]1[CH2:2][CH2:3][CH:4]([c:7]2[n:8][c:9]3[n:10]([c:11]([Cl:26])[cH:12]2)[n:14][cH:15][cH:16]3)[CH2:5][CH2:6]1

Participants

Reactant 3

HCID 949N,N-Dimethylaniline

HCID 24813Phosphorus oxychloride

HCID 178515710HCID 178515710, compound

Product 1

HCID 866678347-Chloro-5-(tetrahydro-2H-thiopyran-4-yl)pyrazolo[1,5-a]pyrimidine

Sources & evidence

ORD record: ord-d375edf3979148e0bbe63d2efe5dc934
Source dataset: Training data from https://doi.org/10.1039/C8SC04228D (1/10)
DOI: 10.1039/C8SC04228D

Reaction notes

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