Dichloromethane → 3-[(4-fluoro-1H-indol-3-yl)methyl]-2-thioxo-1,2,3,7-tetrahydro-6H-purin-6-one

HRID 1542931

Reaction equation

[Cl:30][CH2:31][Cl:32].[F:1][c:2]1[c:3]2[c:4]([CH2:18][n:19]3[c:20](=[S:29])[nH:21][c:22](=[O:28])[c:23]4[nH:24][cH:25][n:26][c:27]34)[cH:5][n:6]([C:11]([O:12][C:13]([CH3:14])([CH3:15])[CH3:16])=[O:17])[c:7]2[cH:8][cH:9][cH:10]1.[F:33][C:34]([F:35])([F:36])[C:37]([OH:38])=[O:39]>>[F:1][c:2]1[c:3]2[c:4]([CH2:18][n:19]3[c:20](=[S:29])[nH:21][c:22](=[O:28])[c:23]4[nH:24][cH:25][n:26][c:27]34)[cH:5][nH:6][c:7]2[cH:8][cH:9][cH:10]1

Participants

Reactant 3

HCID 6344Dichloromethane

HCID 6422Trifluoroacetic acid

HCID 86631124tert-butyl 4-fluoro-3-[(6-oxo-2-thioxo-1,2,6,7-tetrahydro-3H-purin-3-yl)methyl]-1H-indole-1-carboxylate

Product 1

HCID 248555013-[(4-fluoro-1H-indol-3-yl)methyl]-2-thioxo-1,2,3,7-tetrahydro-6H-purin-6-one

Sources & evidence

ORD record: ord-3daa1f858116401f87837475ad7e7397
Source dataset: Training data from https://doi.org/10.1039/C8SC04228D (1/10)
DOI: 10.1039/C8SC04228D

Linked notes

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