Hydrochloric Acid → 3-Chloro-2-[1-(4-chlorophenyl)-1-hydroxymethyl]-5-trifluoromethylpyridine

Reaction equation

[BH4-:1].[CH3:24][CH2:25][OH:26].[Cl:3][c:4]1[c:5]([C:14]([c:15]2[cH:16][cH:17][c:18]([Cl:21])[cH:19][cH:20]2)=[O:22])[n:6][cH:7][c:8]([C:10]([F:11])([F:12])[F:13])[cH:9]1.[ClH:23].[Na+:2]>>[Cl:3][c:4]1[c:5]([CH:14]([c:15]2[cH:16][cH:17][c:18]([Cl:21])[cH:19][cH:20]2)[OH:22])[n:6][cH:7][c:8]([C:10]([F:11])([F:12])[F:13])[cH:9]1

Participants

Reactant 5

HCID 313Hydrochloric Acid

HCID 702Ethanol

HCID 923Sodium Ion

HCID 28123Borohydride

HCID 1478937(4-Chlorophenyl)[3-chloro-5-(trifluoromethyl)-2-pyridinyl]methanone

Product 1

HCID 183272753-Chloro-2-[1-(4-chlorophenyl)-1-hydroxymethyl]-5-trifluoromethylpyridine

Sources & evidence

ORD record: ord-c0dceba0a8054ef09dbc6d6bb336bbd4
Source dataset: Training data from https://doi.org/10.1039/C8SC04228D (1/10)
DOI: 10.1039/C8SC04228D

Reaction notes

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