Piperazine → Ethyl 2-[2-(2,4-difluorophenylamino)-5-fluoro-6-(1-piperazinyl)nicotinoyl]acetate
Reaction equation
[CH2:1]1[CH2:2][NH:3][CH2:4][CH2:5][NH:6]1.[CH2:50]([Cl:51])[Cl:52].[CH3:44][CH2:45][CH2:46][CH2:47][CH2:48][CH3:49].[F:7][c:8]1[c:9]([NH:15][c:16]2[c:17]([C:18](=[O:19])[CH2:20][C:21](=[O:22])[O:23][CH2:24][CH3:25])[cH:26][c:27]([F:43])[c:28]([O:30][S:31]([c:32]3[c:33]([CH3:34])[cH:35][c:36]([CH3:37])[cH:38][c:39]3[CH3:40])(=[O:41])=[O:42])[n:29]2)[cH:10][cH:11][c:12]([F:14])[cH:13]1>>[CH2:1]1[CH2:2][N:3]([c:28]2[c:27]([F:43])[cH:26][c:17]([C:18](=[O:19])[CH2:20][C:21](=[O:22])[O:23][CH2:24][CH3:25])[c:16]([NH:15][c:9]3[c:8]([F:7])[cH:13][c:12]([F:14])[cH:11][cH:10]3)[n:29]2)[CH2:4][CH2:5][NH:6]1Participants
5
