Water → 3-Amino-2-chloro-4-methyl-6-(2,2,2-trifluoro-1-trifluoromethylethoxy)pyridine

Reaction equation

[CH3:19][N:20]([CH3:21])[CH:22]=[O:23].[Cl:24][N:25]=[C:26]([OH:27])[CH2:28][CH2:29][C:30]([OH:31])=[O:32].[NH2:1][c:2]1[c:3]([CH3:18])[cH:4][c:5]([O:8][CH:9]([C:10]([F:11])([F:12])[F:13])[C:14]([F:15])([F:16])[F:17])[n:6][cH:7]1.[OH2:33]>>[NH2:1][c:2]1[c:3]([CH3:18])[cH:4][c:5]([O:8][CH:9]([C:10]([F:11])([F:12])[F:13])[C:14]([F:15])([F:16])[F:17])[n:6][c:7]1[Cl:24]

Participants

Reactant 4

HCID 962Water

HCID 6228Dimethylformamide

HCID 860624455-Amino-4-methyl-2-(2,2,2-trifluoro-1-trifluoromethylethoxy)pyridine

HCID 178525519HCID 178525519, compound

Product 1

HCID 231500063-Amino-2-chloro-4-methyl-6-(2,2,2-trifluoro-1-trifluoromethylethoxy)pyridine

Sources & evidence

ORD record: ord-4acfca7379ee4a659119016486c9f397
Source dataset: Training data from https://doi.org/10.1039/C8SC04228D (1/10)
DOI: 10.1039/C8SC04228D

Reaction notes

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