Methylamine → Azd-7624

Reaction equation

[CH3:36][NH2:37].[Cl:1][CH2:2][CH2:3][O:4][c:5]1[c:6]([C:11]2([NH:14][c:15]3[c:16](=[O:35])[n:17](-[c:21]4[cH:22][c:23]([C:24](=[O:25])[NH:26][CH:27]5[CH2:28][CH2:29]5)[cH:30][c:31]([F:34])[c:32]4[CH3:33])[cH:18][cH:19][n:20]3)[CH2:12][CH2:13]2)[cH:7][cH:8][cH:9][cH:10]1.[O:38]1[CH2:39][CH2:40][O:41][CH2:42][CH2:43]1>>[CH2:2]([CH2:3][O:4][c:5]1[c:6]([C:11]2([NH:14][c:15]3[c:16](=[O:35])[n:17](-[c:21]4[cH:22][c:23]([C:24](=[O:25])[NH:26][CH:27]5[CH2:28][CH2:29]5)[cH:30][c:31]([F:34])[c:32]4[CH3:33])[cH:18][cH:19][n:20]3)[CH2:12][CH2:13]2)[cH:7][cH:8][cH:9][cH:10]1)[NH:37][CH3:36]

Participants

Reactant 3

HCID 6329Methylamine

HCID 312751,4-Dioxane

HCID 666898043-[3-[[1-[2-(2-chloroethoxy)phenyl]cyclopropyl]amino]-2-oxo-1(2H)-pyrazinyl]-N-cyclopropyl-5-fluoro-4-methyl-benzamide

Product 1

HCID 25143624Azd-7624

Sources & evidence

ORD record: ord-47abe848391745baa5a618d0eae1d599
Source dataset: Training data from https://doi.org/10.1039/C8SC04228D (9/10)
DOI: 10.1039/C8SC04228D

Reaction notes

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