Water → 1-Benzyl-4-hydroxy-4-(1,4-benzodioxan-5-yl)piperidine

HRID 1559964

Reaction equation

[Br:6][c:7]1[cH:8][cH:9][cH:10][c:11]2[c:16]1[O:15][CH2:14][CH2:13][O:12]2.[CH2:17]([c:18]1[cH:19][cH:20][cH:21][cH:22][cH:23]1)[N:24]1[CH2:25][CH2:26][C:27](=[O:30])[CH2:28][CH2:29]1.[CH3:32][CH2:33][CH2:34][CH2:35][CH2:36][CH3:37].[Li:1][CH2:2][CH2:3][CH2:4][CH3:5].[O:38]1[CH2:39][CH2:40][CH2:41][CH2:42]1.[OH2:31]>>[c:7]1([C:27]2([OH:30])[CH2:26][CH2:25][N:24]([CH2:17][c:18]3[cH:19][cH:20][cH:21][cH:22][cH:23]3)[CH2:29][CH2:28]2)[cH:8][cH:9][cH:10][c:11]2[c:16]1[O:15][CH2:14][CH2:13][O:12]2

Participants

Reactant 6

HCID 962Water

HCID 8028Tetrahydrofuran

HCID 8058Hexane

HCID 192201-Benzyl-4-piperidone

HCID 187872685-Bromo-2,3-dihydro-1,4-benzodioxine

HCID 178418339Butyllithium

Product 1

HCID 190820021-Benzyl-4-hydroxy-4-(1,4-benzodioxan-5-yl)piperidine

Sources & evidence

ORD record: ord-956079648c7a4c808871ff474a15965e
Source dataset: Training data from https://doi.org/10.1039/C8SC04228D (1/10)
DOI: 10.1039/C8SC04228D

Linked notes

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