Methanol → N-(4-{4-amino-7-[4-(hydroxymethyl)phenyl]thieno[3,2-c]pyridin-3-yl}-2-methoxyphenyl)-1-methyl-1H-indole-2-carboxamide

HRID 1561816Notes

Reaction equation

HRID 1561816 reaction equation
[BH4-:40].[CH3:42][OH:43].[CH3:44][N:45]([CH3:46])[CH:47]=[O:48].[NH2:1][c:2]1[n:3][cH:4][c:5](-[c:32]2[cH:33][cH:34][c:35]([CH:38]=[O:39])[cH:36][cH:37]2)[c:6]2[c:7]1[c:8](-[c:11]1[cH:12][c:13]([O:30][CH3:31])[c:14]([NH:17][C:18](=[O:19])[c:20]3[n:21]([CH3:29])[c:22]4[cH:23][cH:24][cH:25][cH:26][c:27]4[cH:28]3)[cH:15][cH:16]1)[cH:9][s:10]2.[Na+:41].[Na+:49].[Na+:50].[O-:51][C:52](=[O:53])[O-:54]>>[NH2:1][c:2]1[n:3][cH:4][c:5](-[c:32]2[cH:33][cH:34][c:35]([CH2:38][OH:39])[cH:36][cH:37]2)[c:6]2[c:7]1[c:8](-[c:11]1[cH:12][c:13]([O:30][CH3:31])[c:14]([NH:17][C:18](=[O:19])[c:20]3[n:21]([CH3:29])[c:22]4[cH:23][cH:24][cH:25][cH:26][c:27]4[cH:28]3)[cH:15][cH:16]1)[cH:9][s:10]2

Participants

7

Reactant 6

HCID 887MethanolHCID 923Sodium ion3×HCID 6228DimethylformamideHCID 19660Carbonate IonHCID 28123BorohydrideHCID 18451244N-{4-[4-amino-7-(4-formylphenyl)thieno[3,2-c]pyridin-3-yl]-2-methoxyphenyl}-1-methyl-1H-indole-2-carboxamide

Product 1

HCID 18451248N-(4-{4-amino-7-[4-(hydroxymethyl)phenyl]thieno[3,2-c]pyridin-3-yl}-2-methoxyphenyl)-1-methyl-1H-indole-2-carboxamide

Sources & evidence

ORD record
ord-bb406c2e4ef848408d064213be091bbf
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (1/10)

Reaction notes

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