Tetrahydrofuran → tert-Butyl 2-chloro-6-(2,2,2-trifluoro-1-hydroxyethyl)isonicotinate
Reaction equation
[CH2:25]1[O:26][CH2:27][CH2:28][CH2:29]1.[Cl:1][c:2]1[cH:3][c:4]([C:5](=[O:6])[O:7][C:8]([CH3:9])([CH3:10])[CH3:11])[cH:12][c:13]([CH:15]=[O:16])[n:14]1.[F:17][C:18]([F:19])([F:20])[Si:21]([CH3:22])([CH3:23])[CH3:24]>>[Cl:1][c:2]1[cH:3][c:4]([C:5](=[O:6])[O:7][C:8]([CH3:9])([CH3:10])[CH3:11])[cH:12][c:13]([CH:15]([OH:16])[C:18]([F:17])([F:19])[F:20])[n:14]1Participants
4
Sources & evidence
- ORD record
- ord-5e17f308cf74432ca2009c23e1ea2010
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (1/10)
Reaction notes
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