Diethyl Ether → 5-(1,1,1,3,3,3-Hexafluoro-2-hydroxypropan-2-yl)thiazole-2-carbaldehyde
Reaction equation
[Br:12][c:13]1[s:14][c:15]([C:18]([C:19]([F:20])([F:21])[F:22])([C:23]([F:24])([F:25])[F:26])[OH:27])[cH:16][n:17]1.[CH2:1]([Li:2])[CH2:3][CH2:4][CH3:5].[CH3:28][N:29]([CH:30]=[O:31])[CH3:32].[CH3:33][CH2:34][O:35][CH2:36][CH3:37].[CH3:6][CH2:7][CH2:8][CH2:9][CH2:10][CH3:11]>>[c:13]1([CH:30]=[O:31])[s:14][c:15]([C:18]([C:19]([F:20])([F:21])[F:22])([C:23]([F:24])([F:25])[F:26])[OH:27])[cH:16][n:17]1Participants
6
Sources & evidence
- ORD record
- ord-5151a3f8430f40d8947be4733b3327aa
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (1/10)
Reaction notes
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