1-Methylpiperazine → 4-Chloro-2-(4-methoxyphenyl)-6-(4-methyl-1-piperazinyl)-pyrimidine
Reaction equation
Cl[C:2]1[CH:7]=[C:6]([Cl:8])[N:5]=[C:4]([C:9]2[CH:14]=[CH:13][C:12]([O:15][CH3:16])=[CH:11][CH:10]=2)[N:3]=1.[CH3:17][N:18]1[CH2:23][CH2:22][NH:21][CH2:20][CH2:19]1>C(O)C>[Cl:8][C:6]1[CH:7]=[C:2]([N:21]2[CH2:22][CH2:23][N:18]([CH3:17])[CH2:19][CH2:20]2)[N:3]=[C:4]([C:9]2[CH:14]=[CH:13][C:12]([O:15][CH3:16])=[CH:11][CH:10]=2)[N:5]=1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
Employing the procedure of Example XX, 7.7 g. of 4,6-dichloro-2-(4-methoxyphenyl)-pyrimidine is reacted with 6.0 g. of N-methylpiperazine in 45 ml. of absolute ethanol to afford 4-chloro-2-(4-methoxyphenyl)-6-(4-methyl-1-piperazinyl)-pyrimidine, m.p. 88°-90°C.